Schmidt Reaction
Schmidt Reaction It is a rearrangement organic reaction where electrophiles like carbonyls, tertiary alcohols or alkenes react with hydrogen azide to form various products like amines, nitriles, amides or imines with the expulsion of nitrogen. The reaction was discovered by Karl Friedrich Schmidt in 1924 where benzanilide was successfully formed from benzophenone and hydrazoic acid. […]
Hell-Volhard–Zelinsky Reaction
Hell – Volhard- Zelinsky Reaction Hell-Volhard-Zelinsky reaction is the substitution organic reaction which forms alpha halo carboxylic acid from a carboxylic acid having alpha hydrogen in presence of phosphorous halide or phosphorous as a catalyst. The reaction has been named after 3 chemists who discovered this reaction in a period of 1881-1887. The three chemists […]
Elimination Vs. Substitution
Elimination vs. Substitution Substrate Structure (Primary, secondary or tertiary) determines whether elimination or substitution will take place. 2. Less polar solvent (like ethanol) and higher temperature favours elimination. 3. Concentrated KOH and NaOH favours elimination. (Strong base favours elimination and good nucleophile favours substitution).
Factors affecting acidity of carboxylic acids
Factors Affecting Acidity of Carboxylic Acids Two types of groups can be there in structure of carboxylic acid, one is electron withdrawing and other is electron donating. Electron donating groups decreases the acidity and Electron withdrawing groups increases the acidity of carboxylic acid, and also their nearness to carboxylic group creates more impact on acidity […]
Factors affecting basicity of Primary Amines
Factors Affecting Basicity of Primary Amines Two types of groups can be there in the structure of primary amines, one is electron withdrawing and other is electron donating. Electron donating groups increases the basicity and Electron withdrawing groups decreases the basicity of amines as their basicity depends on the availability of free lone pair present […]
Bartoli Indole Synthesis
Bartoli Indole Synthesis This reaction involves the formation of substituted indoles from nitroarene in presence of an excess of vinyl Grignard reagent and aqueous ammonium chloride. The reaction was discovered by Giuseppe Bartoli and his team in the year 1989. The ortho-substituted nitroarene is preferred as they give a good yield. The bulkier group also […]
Corey-Kim Oxidation
Corey-Kim Oxidation It is an organic reaction to form aldehydes and ketones from primary and secondary alcohol. The reaction takes place in presence of N-chlorosuccinimide(NCS), dimethylsulfide(DMS) and triethylamine(TEA). The oxidation reaction was discovered by Nobel laureate Eliar James Corey, American chemist and Choung Un Kim, Korean American chemist in the year 1972. In the mechanism […]
Ullmann Reaction
Ullmann Reaction Ullmann reaction is coupling organic chemistry reaction which forms biaryl by coupling of two molecules of aryl halide in the presence of copper metal and elevated temperature (200°C). The reaction was discovered by Fritz Ullmann. Mechanism of this organic reaction is not clear exactly. There are two proposed mechanisms first is the radical […]
Jones Oxidation
Jones Oxidation It is an oxidation reaction of organic chemistry which leads to the formation of carboxylic acid and ketone. The primary alcohol in presence of chromic trioxide, and sulfuric acid in a mixture of acetone-water (which is also referred as Jones reagent) forms carboxylic acid while secondary alcohol in presence of Jones reagent leads […]
Johnson-Claisen Rearrangement
Johnson – Claisen Rearrangement Johnson-Claisen rearrangement is organic chemistry reaction to form unsaturated ester from allylic alcohol and trialkyl orthoacetate in presence of mildly acidic conditions and heat. The reaction was discovered in 1970 by W.S Johnson and its co-workers. Mechanism of reaction– Firstly alkoxide group is protonated of orthoacetate. Then molecule of alcohol is […]