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Resolution

Resolution

Resolution

The separation of a racemic mixture or racemic modification into pure enantiomers is called resolution. Resolution is a unique technique of separation because it is used to separate the compounds which are having same chemical and physical properties. The process of resolution involves the reaction of racemic acid or base with optically active reagent (base for racemic acids and acid for racemic bases) to generate diastereomers which are easily separable on the basis of the difference in physical properties. The separated diastereomers can be converted to pure enantiomer by reacting with strong acid or base to free it from the salt form of diastereomers.

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