It is a process of discovery of a new molecule depending upon the target receptor. Generally, the drug is a small organic molecule that shows its action either by potentiation or inhibition of biomolecules that are present in the human body.

While designing a molecule it is very important to take care of its shape and charge which should be complementary to the binding site. Drug design is totally based upon the knowledge of the 3D structure of biomolecules and structure-based drug designing is done.


In 1828, Wohler’s prepared urea but it was discovered by chance and containing acyclic structure. Serturner in 1817, isolated pure morphine. Jean Francois extracted opium with alcohol. In 1895, heroin was discovered and in 1930 antihypertensives were available for cardiac treatment. Propranolol synthesis took place in 1963 by James Black.

Chloramphenicol was the first antibiotic manufactured synthetically. In 1952, tetracyclines developed. Nitrogen mustard anticancer drugs developed by goodman and maxwell. Many new molecules came into existence.



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