Retrosynthesis is designing a reverse synthesis of the organic compound. This helps us to find a way to synthesise that compound. Retrosynthesis also gives us an idea about the synthetic steps of a complex compound. Thus by Retrosynthesis, we can convert the target molecule into its simple precursors.
Retrosynthesis plays a great role in designing synthetic routes for complex organic molecules. Retrosynthetic analysis is of great importance in streamlining and optimizing synthetic processes.
Disconnection: A bond is broken to create two (or more) synthons in this retrosynthetic phase.
Retron: A basic molecular framework that facilitates specific chemical reactions.
Synthon: a piece of a substance formed from that target molecule that aids in synthesizing.
Retrosynthetic Analysis (Identification of the target molecule and breaking it down into simpler precursors)
Planning issues in organic synthesis can be addressed using retrosynthetic analysis. To accomplish this, a target molecule is first converted into less reactive and more easily manipulated precursor structures. The same procedure is applied to each potential precursor. This process is repeated until structures are sufficiently simple or readily available commercially. The target molecule can be synthesized using these more straightforward/commercially available chemicals.
When planning a synthesis, the value of retrosynthetic analysis becomes clear. The retrosynthetic analysis aims to simplify structures. Multiple synthetic routes may exist for a given synthesis. Discovering new synthetic routes and comparing them clearly is ideally suited to retrosynthesis.
Functional group tactics: Reducing molecular complexity by manipulating functional groups is a viable strategy.
Methods Employing Stereochemistry: Different stereochemical requirements exist for many chemistry-based objectives. Removing or transferring the desired chirality through stereochemical transformations can help simplify the target.
Objectives-based action plans: Focused investigation is substantially facilitated when a synthesis is guided toward a target intermediate. This paves the way for searches to go in both directions.
Strategies based on transformation: Using transformations in retrosynthetic analysis can significantly simplify the target molecules. Unfortunately, complicated compounds rarely have potent transform-based retrons, and further synthetic steps are often required to confirm their presence.
Methods from topology: It may be necessary to find key substructures or challenging rearrangement transformations after locating one or more key bond disconnections to determine the actual key structures.
We advocate for disconnections that keep rings intact.
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